Increased Risk for Celiac Disease- Early infections matter

by Daquella manera
by Daquella Manera

This study-

Early infections are associated with increased risk for celiac disease: an incident case-referent study

suggests that having repeated infectious episodes under six months old provide increased risk for celiac disease.

Having three or more parental-reported infectious episodes, regardless of type of infection, during the first six months of life was associated with a significantly increased risk for later celiac disease, and this remained after adjusting for infant feeding and socioeconomic status (odds ratio [OR] 1.5; 95% confidence interval [CI], 1.1-2.0; P=0.014). The celiac disease risk increased synergistically if, in addition to having several infectious episodes, infants were introduced to dietary gluten in large amounts, compared to small or medium amounts, after breastfeeding was discontinued (OR 5.6; 95% CI, 3.1-10; P<0.001).

Take Home Message:

Prevent infections in newborns

Introduce gluten in small amounts, preferably while breastfeeding.



Just in case you missed this one- Celiac Disease and Gluten Sensitivity share some common traits .

Conclusion- Celiac Disease, an autoimmune enteropathy, results from an inappropriate T-cell-mediated adaptive immune response against ingested gliadin. In the past few years, though, it has become apparent that “classic” CD represents the tip of the iceberg of an overall disease burden [4,29]. An emerging problem is the clinical characterization of a group of gluten-reactive patients, accounting for roughly 10% of the general population, presenting with symptoms similar to CD but with negative CD serology and histopathology. As in CD, these patients, here and elsewhere referred to as GS [15], experience distress when eating gluten-containing products and show improvement when following a gluten-free diet. Differently from CD, though, in GS the adverse reactions that develop while eating gluten are not followed by the appearance of autoantibodies and by persisting damage to the small intestine. Symptoms in GS may resemble some of the gastrointestinal symptoms that are associated with CD or wheat allergy, but objective diagnostic tests for this condition are currently missing. Therefore, a diagnosis of GS is commonly made by exclusion.

Type 1 diabetes mellitus and celiac disease: a boon to vascular health

Much of my reading and research are deep in conventional medical journals, I want to help everyone to understand what the current research is saying.


I’m going to bring a citation here and then convert it into lay speak.
If you have a question about the translation, feel free to ask in the comments.  This way more folks will be able to ask their physicians important questions and get better care.
Today’s citation comes to us from an Italian Journal of Diabetology.
I’ll interject in This Font
Type 1 diabetes mellitus and celiac disease: endothelial dysfunction.

Acta Diabetol. 2011 Jun 21;

Authors: Picarelli A, Di Tola M, Sabbatella L, Mercuri V, Pietrobono D, Bassotti G, D’Amico T, Donato G, Picarelli G, Marino M, Borghini R, Centanni M, Gargiulo P

Many reports indicate a hypercoagulative state in diabetes mellitus as result of endothelial  damage.

Many reports indicate a clot forming state in diabetes as a result of inner blood vessel wall damage. 


Experimental evidence suggests that a metabolic derangement triggers a cascade of biochemical events that lead to vascular dysfunction.

There is likely a digestive action that sparks the inner blood vessel wall damage

The net effect is to convert the endothelium from thromboresistant to thrombogenic surface.

The net result is to make the inner blood vessel walls likely to form clots

In literature, a strong association between type 1 diabetes mellitus (DM1) and celiac disease (CD) has been reported. We do not have information about the hemostatic system in these associated conditions. Our study aims at evaluating whether the presence of CD in a group of DM1 patients is associated with a different expression of some hemostatic factors and with a different manifestation and/or progression of microvascular complications of DM1 in comparison with patients with only diabetes.


There is a strong association between Type 1 (childhood onset, insulin dependent) Diabetes and Celiac disease.  There is no information about the vascular system in tandem for these diseases

Ninety-four adult DM1 patients were enrolled in the study and subsequently screened for CD. Anti-endomysial antibodies (EMA) were positive in 13 of 94 DM1 patients (13.8%). CD diagnosis was confirmed by histology and organ culture. The mean age and duration of DM1 of patients also affected by CD were similar to those of only diabetic patients, but the metabolic control and the hemocoagulative parameters were significantly different between the two groups:


They researchers gathered 94 diabetic type 1 patients, 13 were proven to have celiac disease by blood test and biopsy. The patients were matched for age and duration of disease, so they should have had similar blood vessel results.

DM1 patients also affected by CD presented significantly lower concentrations of glycosylated hemoglobin (HbA1c) (P < 0.05), cholesterol (P < 0.001), triglycerides (P < 0.001), factor VII antigen (FVII:ag) (P < 0.005), factor VII coagulant activity (FVII:c) (P < 0.05), and prothrombin degradation fragments (F1+2) (P < 0.001), as well as higher values of activated C protein (APC) (<0.001). No retinal abnormalities and no signs of renal damage were observed in DM1 patients also affected by CD.

Our results suggest a potential protective role of CD in the prothrombotic state of DM1.

PMID: 21691748 [PubMed – as supplied by publisher]

 Their results suggest a Protective role of celiac disease in the blood vessel viability of Type 1 Diabetic patients by reducing the Hemoglobin A1C number, cholesterol, triglycerides, and coagulation evalulatory labs. 


So this suggests that being celiac might help a type 1 diabetic avoid some of the common problems of diabetes.

Was this interesting?  Are you curious to learn more about the pluses and minuses of celiac and gluten intoleranc

Mortality of Undiagnosed Celiacs

400% Increase in Risk of Death for Undiagnosed Celiacs 04/22/2009 – Not many studies have looked at prevalence and long-term outcome of undiagnosed celiac disease, and so not much is known about this aspect of the disease. Recently, a team of Mayo Clinic researchers conducted an assessment of the long-term outcome of undiagnosed celiac disease, and whether the prevalence of undiagnosed celiac disease has changed during the past 50 years.

The research team was made up of Alberto Rubio-Tapia, MD; Robert A. Kyle, MD; Edward L. Kaplan, MD; Dwight R. Johnson, MD; William Page, PhD; Frederick Erdtmann, MD, MPH; Tricia L. Brantner, MD; W. Ray Kim, MD, Tara K. Phelps, MS; Brian D. Lahr, MS; Alan R. Zinsmeister, PhD; L. Joseph Melton III, MD; and Joseph A. Murray, MD.

For the study the team looked at blood samples taken from 9,133 healthy young adults at Warren Air Force Base between 1948 and 1954, along with samples from 12,768 sex-matched subjects from 2 recent cohorts from Olmsted County, Minnesota. Subjects from the Minnesota cohorts were matched for date of birth (n=5,558) or age at sampling (n=7,210) with the Air Force study.

The research team tested the blood samples for tissue transglutaminase and, if abnormally high, for endomysial antibodies. They charted survival rates in a 45 year follow-up period in the Air Force and compared rates of undiagnosed celiac between the Air Force data and the recent cohorts.

Of 9,133 Air Force subjects, 14 had undiagnosed celiac disease–a rate of 0.2%. In that cohort, persons with undiagnosed celiac disease had higher mortality rates across the board than those who had tested negative (hazard ratio=3.9; 95% CI, 2.0-7.5; P <.001).

In the case of the Minnesota cohorts, the team found undiagnosed celiac disease in 68 persons with similar age at sampling (0.9%), and 46 persons with similar years of birth (0.8%). These recent cohorts showed rates of undiagnosed celiac disease that were 4.5-times and 4-times greater than the Air Force cohort (both P=.0001).

The research team found that data from the 45 year of follow-up of Air Force subjects showed that people with undiagnosed celiac disease have a 400% higher risk of death than seronegative subjects (“non-celiacs”). They also concluded that rates of undiagnosed celiac disease seem have increased dramatically in the United States over the last 50 years.

Gastroenterology – 13 April 2009 (10.1053/j.gastro.2009.03.059).

Feed the ones who need the support

This is from a blog that I love to follow.

Please consider buying their book to support this amazing donation to the food bank.

Gluten-Free Sales Proceeds to Charity this YEAR
UPDATE: we have extended this charity-event to the entire year (2009).

I have been deeply concerned with the state of the economy, how quickly it is degrading, and how this is impacting people throughout the United States – especially those unfortunate enough to be on the receiving end of a layoff or other forced unemployment.

I was watching 60 minutes last week when they were detailing the unemployment carnage in Wilmington, OH (where the Airborne Express / DHL company is closing, and leaving nearly 1/4 of the town unemployed – 3,000 workers thus far). And then there is the nearly daily nightly news report about mass layoffs somewhere, and rising unemployment. And, another sub-story to all this is the escalating demand for services from local Food Banks and other charitable organizations.

So, my wife and I have decided that for 2009, we will be donating all proceeds from the sales of our Gluten-Free & Wheat-Free Gourmet Desserts books (link) to charity — either regional or local food bank(s) and/or homeless shelter(s).

Notice I am not limiting the donation to “all profits” from the books sales (since “profits” is a term subject to manipulation), but rather I am saying that we will donate the entire amount collected for each book sold throughout the month:
without any limit on quantity (well, up to whatever books we have printed, which should be plenty);
with the only exception being the shipping charge, which already goes to employ another group of people whose business is in decline: Postal Workers and shipping-products-producers (i.e., box-manufacturers, tape producers, bubble-wrap suppliers).
I could not help thinking how difficult it would be to maintain a wheat-free or gluten-free diet, should someone end up at a charitable food-bank. This is something I do not know how to address easily with charitable giving… I can only hope that some shelters or assistance organizations are able to accommodate special needs when they must, though I fear it is unlikely. Regardless, gluten-free or not, I just want to know that we have at least tried to help those less fortunate in a time of need.

Finally, to anyone that decides to purchase a book during 2009, we thank you as always, and in addition, any recipient of donations resulting from our sales would certainly thank you too if they could. And to anyone reading this Gluten-Free Blog and facing financial hardships of their own, we wish you the best and hope things work out well for you ASAP.
Posted by Mike Eberhart at Monday, February 02, 2009